Travel guide
Florida Keys Road Trip: From Key Largo to Key West
A one-tank drive through mangrove islands, fishing towns, and sunset bars — with the best stops from the Upper Keys to Key West.
6 min readUpdated August 16, 2026
The Overseas Highway
US-1 is the attraction itself. The 113-mile drive from Key Largo to Key West crosses 42 bridges, including the famous Seven Mile Bridge. Start early, stop often, and don't rush.
Best stops along the way
- John Pennekamp Coral Reef State Park in Key Largo
- Feeding tarpon at Robbie's Marina in Islamorada
- The Turtle Hospital in Marathon
- Big Pine Key's Key Deer National Wildlife Refuge
- Sunset at Mallory Square in Key West
Where to stay
Split the trip: a canal-front home in Islamorada or Marathon for fishing and kayaking, then a conch cottage in Key West for walking, dining, and nightlife.
Planning a Florida Keys stay?
Read the full Florida Keys destination guide — neighborhoods, seasons, and booking tips — then browse example rentals.
